HCID 86711550, compound → HCID 86711564, compound

HRID 512517Notes

Reaction equation

HRID 512517 reaction equation
[CH3:1][NH:2]C(C1C(=O)C(C2C=CN=C(C(F)(F)F)C=2)=C(C)N(C(C2C=CC(Br)=CN=2)C)C=1)=O.[CH3:32][NH:33][C:34]([C:36]1[C:37](=[O:63])[C:38]([C:53]2[CH:58]=[CH:57][N:56]=[C:55]([C:59]([F:62])([F:61])[F:60])[CH:54]=2)=[C:39]([CH3:52])[N:40]([CH:42]([C:45]2[CH:50]=[CH:49][C:48](Br)=[CH:47][CH:46]=2)[CH2:43][CH3:44])[CH:41]=1)=[O:35]>>[CH3:32][NH:33][C:34]([C:36]1[C:37](=[O:63])[C:38]([C:53]2[CH:58]=[CH:57][N:56]=[C:55]([C:59]([F:62])([F:61])[F:60])[CH:54]=2)=[C:39]([CH3:52])[N:40]([CH:42]([C:45]2[CH:50]=[CH:49][C:48]([C:1]#[N:2])=[CH:47][CH:46]=2)[CH2:43][CH3:44])[CH:41]=1)=[O:35]

Participants

3

Reactant 2

HCID 86711550HCID 86711550, compoundHCID 86711565HCID 86711565, compound

Product 1

HCID 86711564HCID 86711564, compound

Procedure

Example 36 is prepared as described for Example 15, substituting preparation 15b with preparation 36b. ESI mass spectrum: [M+H]+=455; Retention time HPLC: 0.85 min (Z011_S03).

Workup

  1. customExample 36 is prepared

Sources & evidence

ORD record
ord-24f138289f9a4d4bbb2a5cead3212d36
Source dataset
uspto-grants-2015_08
Patent number
US09102624B2

Reaction notes

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