HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)-3-fluorobenzonitrile → 1-(4-Cyano-2-fluoro-benzyl)-5-(3-difluoromethyl-phenyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)-3-fluorobenzonitrile | HCID 2783149 | — |
| Reactant | 5-(3-Difluoromethyl-phenyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide | HCID 86711567 | — |
| Product | 1-(4-Cyano-2-fluoro-benzyl)-5-(3-difluoromethyl-phenyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide | HCID 86711569 | — |
Reaction Steps
Example 41 is prepared as described for example 2.1, substituting benzyl bromide with 4-bromomethyl-3-fluoro-benzonitrile and substituting preparation 5 with preparation 39a. ESI mass spectrum: [M+H]+=580; Retention time HPLC: 1.02 min (Z018_S04).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102624B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-3c30274c4a9943cea4e726a7be25e966 |
| Source note | uspto-grants-2015_08 |