HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyano-3-fluorobenzyl bromide → 1-(4-Cyano-3-fluoro-benzyl)-2-methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyano-3-fluorobenzyl bromide | HCID 2778466 | — |
| Reactant | 2-Methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid methylamide | HCID 86711571 | — |
| Product | 1-(4-Cyano-3-fluoro-benzyl)-2-methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid methylamide | HCID 86711572 | — |
Reaction Steps
Example 43 is prepared as described for example 2.1, substituting benzyl bromide with 4-bromomethyl-2-fluoro-benzonitrile and substituting preparation 5 with preparation 36a. ESI mass spectrum: [M+H]+=445; Retention time HPLC: 0.97 min (Z018_S04).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102624B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-a6825938fb2f47b69e4d33316257a0c3 |
| Source note | uspto-grants-2015_08 |