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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512522Generated: October 27, 2026

6-(Bromomethyl)pyridine-3-carbonitrile → 1-(5-Cyano-pyridin-2-ylmethyl)-2-methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid methylamide

https://huagongshe.com/reaction/512522

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(Bromomethyl)pyridine-3-carbonitrileHCID 21927776—
Reactant2-Methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid methylamideHCID 86711571—
Product1-(5-Cyano-pyridin-2-ylmethyl)-2-methyl-4-oxo-2'-trifluoromethyl-1,4-dihydro-[3,4']bipyridinyl-5-carboxylic acid methylamideHCID 86711573—

Reaction Steps

Example 44 is prepared as described for example 2.1, substituting benzyl bromide with 6-bromomethyl-nicotinonitrile and substituting preparation 5 with preparation 36a. ESI mass spectrum: [M+H]+=428; Retention time HPLC: 0.99 min (Z018_S04).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102624B2
Source datasetuspto-grants-2015_08
ORD IDord-62c6710df9b24fa790a0c51677cecd73
Source noteuspto-grants-2015_08