反应详情

To a suspension of 2-amino-2-cyanoacetamide (0.25 g, 2.53 mmol) in EtOAc (8 mL), was added 1-isothiocyanatonaphthalene (0.467 g, 2.53 mmol), and the mixture was refluxed for 30 min. The solvent was evaporated under reduced pressure, and the resulting crude residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.35 g (48% yield) of the titled compound.

1. temperaturethe mixture was refluxed for 30 min
2. customThe solvent was evaporated under reduced pressure
3. customthe resulting crude residue was purified by silica gel column chromatography
4. washeluted with 2% MeOH in DCM