2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-6-ylamino)thiazole-4-carboxamide

Participants

Reaction Steps

A mixture of 6-isothiocyanatoquinoline (0.50 g, 2.7 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the residue was purified by silica gel column chromatography eluted with 2% MeOH in DCM to give 0.50 g (65% yield) of the titled compound.

Provenance & Evidence