Morpholine → 5-(6-Morpholinohexanamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(6-bromohexanamido)-2-(naphthalen-2-ylamino)thiazole-4-carboxamide (150 mg, 0.32 mmol) and morpholine (0.06 mL, 0.69 mmol) in DMA (0.5 ml) was heated at 120° C. for 1.5 hrs in a sealed tube. The reaction mixture was then diluted with ice-water. The resulting solids were collected by filtration and washed successively with ether and MeOH to give 135 mg (90% yield) of the titled compound.

Provenance & Evidence