Dimethylformamide → HCID 66677988, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-(4-hydroxy-2,6-dimethylphenyl)cyclohexane-1,3-dione (0.200 g, 0.0009 mol), 2,6-dichloroquinoline (0.170 g, 0.0009 mol) and potassium carbonate (0.350 g, 0.0025 mol) is added N,N-dimethylformamide (3 ml), and the mixture is heated at 140° C. for 40 minutes under microwave irradiation. The reaction mixture is then diluted with ethyl acetate (20 ml) and 2M hydrochloric acid (20 ml), and the organic phase is separated, dried over magnesium sulfate and evaporated under reduced pressure. The crude product is purified by preparative reverse phase HPLC to afford 2-[4-(6-chloroquinolin-3-yloxy)-2,6-dimethylphenyl]cyclohexane-1,3-dione as a cream solid.

Provenance & Evidence