HRID512603

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58432042

未命名化合物

HCID58432125

未命名化合物

HCID86657501

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2coc(C(=O)C(OC)c3ccc(OC(C)C)cc3)n2)cc(OC)c1Br

HCID58432052

未命名化合物

HCID86657501

未命名化合物

PROCEDURE

实验过程

2-(4-Isopropoxyphenyl)-N,2-dimethoxy-N-methylacetamide was synthesized from 2-(4-isopropoxyphenyl)-2-methoxyacetic acid following the method used for the synthesis of Example 1. 1-(4-(4-Bromo-3,5-dimethoxyphenyl)oxazol-2-yl)-2-(4-isopropoxyphenyl)-2-methoxyethanone was synthesized from 2-(4-isopropoxyphenyl)-N,2-dimethoxy-N-methylacetamide and 4-(4-bromo-3,5-dimethoxyphenyl)oxazole following the method used for the synthesis of Example 7. MS: m/z 490.1 [M+H]+.

WORKUP

后处理

customused for the synthesis of Example 1
customused for the synthesis of Example 7

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-11cf0cb9ce3942f0a9ff1fff3f5f41a0
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09102643B2
来源说明: uspto-grants-2015_08

反应 SMILES

[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([O:15][CH3:16])[C:12]([OH:14])=O)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[CH:17]([O:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]([O:34][CH3:35])[C:28]([N:30]([O:32][CH3:33])[CH3:31])=[O:29])=[CH:23][CH:22]=1)([CH3:19])[CH3:18].[Br:36][C:37]1[C:42]([O:43][CH3:44])=[CH:41][C:40]([C:45]2[N:46]=[CH:47][O:48][CH:49]=2)=[CH:39][C:38]=1[O:50][CH3:51]>>[CH:17]([O:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]([O:34][CH3:35])[C:28]([N:30]([O:32][CH3:33])[CH3:31])=[O:29])=[CH:23][CH:22]=1)([CH3:19])[CH3:18].[Br:36][C:37]1[C:42]([O:43][CH3:44])=[CH:41][C:40]([C:45]2[N:46]=[C:47]([C:12](=[O:14])[CH:11]([C:8]3[CH:7]=[CH:6][C:5]([O:4][CH:1]([CH3:2])[CH3:3])=[CH:10][CH:9]=3)[O:15][CH3:16])[O:48][CH:49]=2)=[CH:39][C:38]=1[O:50][CH3:51]