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HRID512634

反应详情

EQUATION

反应方程式

HRID 512634 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[Si](C)(C)OCc1ccc(C(=O)NN)cc1
HCID10707914

4-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]benzoic acid hydrazide

C14H24N2O2Si

结构：CCOC(=N)C1CC1.Cl
HCID20026660

Ethyl cyclopropanecarboximidate--hydrogen chloride (1/1)

C6H12ClNO

PRODUCTS

生成物

1
结构：CC(C)(C)[Si](C)(C)OCc1ccc(-c2nnc(C3CC3)o2)cc1
HCID58432005

未命名化合物

收率 40%

PROCEDURE

实验过程

4-(((Tert-butyldimethylsilyl)oxy)methyl)benzohydrazide was reacted with ethyl cyclopropanecarbimidate hydrochloride according to the procedure used for the synthesis of Example 18. Purification by chromatography (EtOAc-hexanes) gave 2-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-5-cyclopropyl-1,3,4-oxadiazole as a brown oil (3.7 g, 40% yield).

WORKUP

后处理

  1. customused for the synthesis of Example 18
  2. customPurification by chromatography (EtOAc-hexanes)