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HRID512636

反应详情

EQUATION

反应方程式

HRID 512636 的结构方程式

REACTANTS

反应物

2
结构：COc1cc(-c2ccco2)cc(OC)c1Br
HCID58431988

未命名化合物

结构：COC(C(=O)N(C)OC)c1ccc(N2CCCCC2)nc1
HCID58432037

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(-c2ccc(C(=O)C(OC)c3ccc(N4CCCCC4)nc3)o2)cc(OC)c1Br
HCID58432157

未命名化合物

收率 65%

PROCEDURE

实验过程

N,2-Dimethoxy-N-methyl-2-(6-(piperidin-1-yl)pyridin-3-yl)acetamide was reacted with 2-(4-bromo-3,5-dimethoxyphenyl)furan according to the procedure used for Example 12. Purification by chromatography (20-75% EtOAc-hexanes) gave 1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(6-(piperidin-1-yl)pyridin-3-yl)ethanone as a light yellow solid (0.328 g, 65% yield). MS: m/z 515.4 [M+H]+.

WORKUP

后处理

  1. customPurification by chromatography (20-75% EtOAc-hexanes)