HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 3-(3-chloro-4-nitro-1H-pyrazol-1-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 3-(3-chloro-1H-pyrazol-1-yl)pyridine | HCID 67499540 | — |
| Product | 3-(3-chloro-4-nitro-1H-pyrazol-1-yl)pyridine | HCID 67500148 | — |
Reaction Steps
In step d of Scheme 1, compound (5b) is nitrated with nitric acid (HNO3), preferably in the presence of sulfuric acid (H2SO4) to yield 3-(3-chloro-4-nitro-1H-pyrazol-1-yl)pyridine (5c). The nitration may be conducted at temperatures from about −10° C. to about 30° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102654B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-bf25e7b693254f6f9399714fb9ce2282 |
| Source note | uspto-grants-2015_08 |