HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 51277Generated: October 26, 2026
Dimethylformamide → 4-Fluorophenylacetyl chloride
https://huagongshe.com/reaction/51277
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-(4-Fluorophenyl)acetic acid | HCID 9837 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Fluorophenylacetyl chloride | HCID 3744988 | — |
Reaction Steps
Into a suitable agitated reactor is charged 4-fluorophenylacetic acid (79.4 kg, 515 mol), N,N-dimethylformamide (0.5 kg, 6.8 mol), and toluene (318 kg). Oxalyl chloride (68.3 kg, 538 mol) is added at a rate as to maintain the temperature below 35° C. The solution is stirred for at least 7 hours at about 25° C., typically affording a 22.1 wt % solution of 4-fluorophenylacetyl chloride.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06713627B2 |
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| Source dataset | uspto-grants-2004_03 |
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| ORD ID | ord-8fc5d48602a040af9095623c7c408705 |
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| Source note | uspto-grants-2004_03 |
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