HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3,5-Dichloro-4-fluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3,5-Dichloro-4-fluorobenzoic acid | HCID 19971303 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3,5-Dichloro-4-fluorobenzoyl chloride | HCID 19612379 | — |
Reaction Steps
3,5-dichloro-4-fluorobenzoic acid was refluxed with >1 equivalent of thionyl chloride and one drop of DMF neat or as a solution in CHCl3. The solvent and volatile by-products were removed in vacuo to provide 3,5-dichloro-4-fluorobenzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102648B1 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-b35df1ffa7874a66994d292a8084a565 |
| Source note | uspto-grants-2015_08 |