1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester → 1-(1-(6-(1-ethyl-1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline
Reaction equation
[CH2:1]([N:3]1[CH:7]=[C:6](B2OC(C)(C)C(C)(C)O2)[CH:5]=[N:4]1)[CH3:2].Cl[C:18]1[N:23]=[N:22][C:21]([N:24]2[CH2:29][CH2:28][CH:27]([N:30]3[C:38]4[C:33](=[CH:34][CH:35]=[C:36]([F:39])[CH:37]=4)[CH2:32][CH2:31]3)[CH2:26][CH2:25]2)=[CH:20][CH:19]=1>>[CH2:1]([N:3]1[CH:7]=[C:6]([C:18]2[N:23]=[N:22][C:21]([N:24]3[CH2:25][CH2:26][CH:27]([N:30]4[C:38]5[C:33](=[CH:34][CH:35]=[C:36]([F:39])[CH:37]=5)[CH2:32][CH2:31]4)[CH2:28][CH2:29]3)=[CH:20][CH:19]=2)[CH:5]=[N:4]1)[CH3:2]Participants
3
Procedure
The title compound was prepared following the procedure as described in Example 1, Method A, reacting 1-ethylpyrazole-4-boronic acid pinacol ester and 1-(1-(6-chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline.
Sources & evidence
- ORD record
- ord-d5754e1a87bd459aa7f77e2ea4642094
- Source dataset
- uspto-grants-2015_08
- Patent number
- US09102669B2
Reaction notes
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