4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 1-(1-(6-(1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline

HRID 512848Notes

Reaction equation

HRID 512848 reaction equation
[NH:1]1[CH:5]=[C:4](B2OC(C)(C)C(C)(C)O2)[CH:3]=[N:2]1.Cl[C:16]1[N:21]=[N:20][C:19]([N:22]2[CH2:27][CH2:26][CH:25]([N:28]3[C:36]4[C:31](=[CH:32][CH:33]=[C:34]([F:37])[CH:35]=4)[CH2:30][CH2:29]3)[CH2:24][CH2:23]2)=[CH:18][CH:17]=1>>[NH:2]1[CH:3]=[C:4]([C:16]2[N:21]=[N:20][C:19]([N:22]3[CH2:23][CH2:24][CH:25]([N:28]4[C:36]5[C:31](=[CH:32][CH:33]=[C:34]([F:37])[CH:35]=5)[CH2:30][CH2:29]4)[CH2:26][CH2:27]3)=[CH:18][CH:17]=2)[CH:5]=[N:1]1

Participants

3

Reactant 2

HCID 27740104-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 896144661-(1-(6-Chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline

Product 1

HCID 896139441-(1-(6-(1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline

Procedure

1-(1-(6-(1H-pyrazol-4-yl)pyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline was prepared according to the procedure described in Example 1, Method A, STEP 4, reacting pyrazole-4-boronic acid pinacol ester and 1-(1-(6-chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline.

Sources & evidence

ORD record
ord-f87a290b5b164e77b1efe621f60159ce
Source dataset
uspto-grants-2015_08
Patent number
US09102669B2

Reaction notes

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