2-Methylpyridine-5-boronic acid → HCID 71585291, compound

HRID 512857Notes

Reaction equation

HRID 512857 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][N:3]=1.Cl[C:12]1[N:17]=[N:16][C:15]([N:18]2[CH2:23][CH2:22][CH:21]([N:24]3[C:32]4[C:27](=[CH:28][CH:29]=[C:30]([F:33])[CH:31]=4)[CH2:26][CH2:25]3)[CH2:20][CH2:19]2)=[CH:14][CH:13]=1>>[F:33][C:30]1[CH:31]=[C:32]2[C:27]([CH2:26][CH2:25][N:24]2[CH:21]2[CH2:22][CH2:23][N:18]([C:15]3[N:16]=[N:17][C:12]([C:5]4[CH:4]=[N:3][C:2]([CH3:1])=[CH:7][CH:6]=4)=[CH:13][CH:14]=3)[CH2:19][CH2:20]2)=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 27630812-Methylpyridine-5-boronic acidHCID 896144661-(1-(6-Chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline

Product 1

HCID 71585291HCID 71585291, compound

Procedure

The title compound was prepared following the procedure as described in Example 1, Method A, STEP4, reacting 2-methylpyridine-5-boronic acid and 1-(1-(6-chloropyridazin-3-yl)piperidin-4-yl)-6-fluoroindoline.

Sources & evidence

ORD record
ord-f11f02f2af50430f990a456ec907dca4
Source dataset
uspto-grants-2015_08
Patent number
US09102669B2

Reaction notes

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