Water → HCID 178504137, compound

Participants

Reaction Steps

(Ia.64): To a stirred solution of chloro-amide 28a (0.5 g, 0.93 mmol) in tetrahydrofuran (20 ml) kept under nitrogen was added 2-mercaptoaceticacid (0.130 g, 1.87 mmol) and potassium tert-butoxide (0.210 g, 1.87 mmol). The reaction mass was stirred for 5 hours, poured into water (100 ml) and acidified with glacial acetic acid (10 ml) followed by usual workup in ethylacetate and evaporation to give the residue. The resulted residue was purified by FC followed by trituration with hexane to afford (Ia.64) (0.2 g, 36%) as a pale yellow solid.

Provenance & Evidence