HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512920Generated: October 30, 2026
Acetic Acid → 2-[2-(2-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-2-hydroxy-ethoxy)-phenyl]-propan-2-ol
https://huagongshe.com/reaction/512920
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-(2-Hydroxypropan-2-yl)phenol | HCID 827955 | — |
| Reactant | 7-Chloro-2-[(E)-2-(3-oxiranyl-phenyl)-vinyl]-quinoline | HCID 86720731 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-[2-(2-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-2-hydroxy-ethoxy)-phenyl]-propan-2-ol | HCID 86720732 | 46.7% |
Reaction Steps
To a stirred solution of epoxide 30 (10.0 g, 32.57 mmol) in DMF (30 ml) was added alcohol 31 (7.425 g, 48.85 mmol), potassium carbonate (8.99 g, 65.14 mmol). The reaction mixture was stirred overnight at 120-130° C. The resulted mixture was treated with 10% aq. acetic acid, diluted further with water followed by usual workup in ethyl acetate and FC to give diol 32 (7.0 g, 46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09102665B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-b93abc29ee7a4ad08b3fb18378423ee9 |
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| Source note | uspto-grants-2015_08 |
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