Iodine → Ethyl 5-iodopyrazolo[1,5-a]pyridine-3-carboxylate

HRID 513033Notes

Reaction equation

HRID 513033 reaction equation
N[C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:4]2[CH:3]=1.B(F)(F)F.CCOCC.N(OCCC(C)C)=O.[I:33]I.O.O.O.O.O.S([O-])([O-])(=O)=S.[Na+].[Na+]>O.CC#N>[I:33][C:2]1[CH:7]=[CH:6][N:5]2[N:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:4]2[CH:3]=1

Participants

8

Reactant 5

HCID 807IodineHCID 8000Boron trifluoride etherateHCID 8053Isoamyl NitriteHCID 61475Sodium Thiosulfate PentahydrateHCID 59476232Ethyl 5-aminopyrazolo[1,5-a]pyridine-3-carboxylate

Product 1

HCID 68503386Ethyl 5-iodopyrazolo[1,5-a]pyridine-3-carboxylate

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Conditions

Temperature
10 °C

Procedure

A 2 L round bottom flask was charged with ethyl 5-aminopyrazolo[1,5-a]pyridine-3-carboxylate (I-40) (28.8 g, 140 mmol) and CH3CN (450 mL). The suspension was cooled to 10° C. and BF3.Et2O (26.3 mL, 29.7 g, 209 mmol) was added in one portion. The resulting light slurry was cooled to −15° C. and isopentyl nitrite (28 mL, 24.5 g, 209 mmol) was added at −15 to −10° C. over 5 minutes. The mixture was then warmed to 0° C. and stirred at 0-5° C. over 2 hours and a dark suspension was obtained. Iodine (2.7 g, 11 mmol) and KI (35.1 g, 166 mmol) were added at 0 to 5° C. in portions over 2 minutes. A dark mixture was obtained with gas evolution. The mixture was warmed to 20° C. and stirred at 20° C. over 4 hours. A sample was taken for analysis and HPLC showed consumption of the diazonium intermediate. A solution of sodium thiosulfate pentahydrate (75 g, 302 mmol) in water (450 mL) was added and the mixture was stirred at 20° C. over 5 hours. The mixture was cooled to 0-5° C. and stirred at 0-5° C. over 30 minutes. The slurry was filtered and the solid cake was rinsed with CH3CN/H2O (1:1, 400 mL) and water (400 mL). The solid was air dried over 72 hours to give ethyl 5-iodopyrazolo[1,5-a]pyridine-3-carboxylate (I-41) as a red solid. 1H NMR (500 MHz, DMSO-d6) δ 8.64 (d, 1 H), 8.41 (d, 1 H), 8.40 (s, 1 H), 7.39 (dd, 1 H), 4.31 (q, 2 H), 1.34 (t, 3 H).

Workup

  1. temperatureThe resulting light slurry was cooled to −15° C.
  2. temperatureThe mixture was then warmed to 0° C.
  3. customa dark suspension was obtained
  4. customA dark mixture was obtained with gas evolution
  5. temperatureThe mixture was warmed to 20° C.
  6. stirringstirred at 20° C. over 4 hours
  7. customconsumption of the diazonium intermediate
  8. stirringthe mixture was stirred at 20° C. over 5 hours
  9. temperatureThe mixture was cooled to 0-5° C.
  10. stirringstirred at 0-5° C. over 30 minutes
  11. filtrationThe slurry was filtered
  12. washthe solid cake was rinsed with CH3CN/H2O (1:1, 400 mL) and water (400 mL)
  13. customdried over 72 hours

Sources & evidence

ORD record
ord-a63a78c7a53444df837986e61b84bf8b
Source dataset
uspto-grants-2015_08
Patent number
US09102671B2

Reaction notes

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