Trifluoroacetic acid → HCID 66684295, compound

Participants

Reaction Steps

To a solution of (R)-tert-butyl 4,4-difluoro-2-(5-fluoro-2-(isopropylcarbamoyl)phenyl)pyrrolidine-1-carboxylate (I-50) (203 mg, 0.525 mmol) in DCM (0.4 mL) was added TFA (1 mL). After stirring for 2 hours the mixture was concentrated to dryness, diluted with DCM, washed with saturated aqueous NaHCO3 and brine, dried over sodium sulfate and concentrated to dryness to give (R)-2-(4,4-difluoropyrrolidin-2-yl)-4-fluoro-N-isopropylbenzamide (I-51) as a pale brown solid. MS m/z 287.1 (M+H)+. 1-51 was also isolated as a racemic mixture using un-resolved 1-45A and 1-45B from Method A in the above sequence.

Provenance & Evidence