反应详情

A mixture of 430 mg. of the product from Example 3 Part D, 2.0 gm. of 5% Pd/C, and 20 mL of carbitol was heated to reflux and refluxed for 21 hours, cooled, and filtered. The filtrate was diluted with water, acidified with hydrochloric acid, and extracted well with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate and evaporated in vacuo. The residue was triturated with dichloromethane and filtered to remove solid tetrahydrocarbazole. The filtrate was evaporated in vacuo to give the title product, 125 mg, 31%.

1. additionA mixture of 430 mg
2. temperatureto reflux
3. temperaturerefluxed for 21 hours
4. temperaturecooled
5. filtrationfiltered
6. additionThe filtrate was diluted with water
7. extractionextracted well with ethyl acetate
8. washThe organic phase was washed with brine
9. dry with materialdried over sodium sulfate
10. customevaporated in vacuo
11. customThe residue was triturated with dichloromethane
12. filtrationfiltered
13. customto remove solid tetrahydrocarbazole
14. customThe filtrate was evaporated in vacuo