2,3-Difluorobenzoyl chloride → HCID 67505670, compound

HRID 513122Notes

Reaction equation

HRID 513122 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([NH:6]C(OC(C)(C)C)=O)=[CH:4][CH:3]=1.[F:16][C:17]1[C:25]([F:26])=[CH:24][CH:23]=[CH:22][C:18]=1[C:19](Cl)=[O:20]>>[NH2:6][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:15][C:14]=1[C:19]([C:18]1[CH:22]=[CH:23][CH:24]=[C:25]([F:26])[C:17]=1[F:16])=[O:20]

Participants

3

Reactant 2

HCID 5195492,3-Difluorobenzoyl chlorideHCID 546372tert-butyl N-(4-chlorophenyl)carbamate

Product 1

HCID 67505670HCID 67505670, compoundYield 14%

Procedure

In a manner similar to that described above for compound 1aa, 4-Chloro-N-Boc-aniline and 2,3-difluoro-benzoyl chloride were converted to 1v (14% yield) MS m/z=268 (M+H).

Sources & evidence

ORD record
ord-274089405b934aa8aaf6fd55eb8e44e6
Source dataset
uspto-grants-2015_08
Patent number
US09102678B2

Reaction notes

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