Ethanol → HCID 86720580, compound

Participants

Reaction Steps

To a solution of 1-tert-butyl 2-ethyl 7-chloro-3-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[2,3-c]pyridine-1,2-dicarboxylate (33 mg, 0.06 mmol) in THF (1 mL) was added EtOH (0.2 mL)m and water (0.2 mL). Solid LiOH (30 mg, 1.2 mmol) was then added in a single portion. After 2.5 h, quenched with 5% potassium bisulfate until acidic (˜pH 3) and extracted with Et2O and then EtOAc. The combined organic layer was dried over MgSO4, filtered, and concentrated in vacuo to yield the title compound (30 mg). LRMS (ESI) calc (M+H)+=501.1. found 501.2.

Provenance & Evidence