Water → Trifluoroacetic acid

Participants

Reaction Steps

To a solution of 1-(tert-butoxycarbonyl)-7-chloro-3-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid (9.4 mg, 0.019 mmol) in DCM (0.5 mL) was added water (0.01 mL), dimethylsulfide (0.01 mL), and then TFA (0.5 mL, 6.5 mmol). Upon complete consumption of starting material, the mixture was concentrated in vacuo to yield the title compound as a TFA salt (7.8 mg). HRMS (ESI) calc (M+H)+=401.0510. found 401.0509.

Provenance & Evidence