HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Chloro-3-(trifluoromethyl)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Chloro-3-(trifluoromethyl)benzoic acid | HCID 2736677 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-3-(trifluoromethyl)benzoyl chloride | HCID 3827633 | — |
Reaction Steps
To a suspension of 2-chloro-3-(trifluoromethyl)benzoic acid (15 g, 67 mmol) and catalytic DMF (0.06 mL, 0.67 mmol) in DCM (150 mL) was added oxalyl chloride (6.8 mL, 80 mmol) dropwise. The reaction was let stir (vigorous bubbling) for 4 h and concentrated to an oily solid which became solid after overnight drying on high vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102686B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-7e8ac219a9984f6494b1041233e4e050 |
| Source note | uspto-grants-2015_08 |