HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 117599757, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 117600182 | HCID 117600182 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 117599757 | HCID 117599757 | — |
Reaction Steps
4-Bromo-2-(3-fluoro-5-methoxy-benzoyl)-benzoic acid (140 mg; 0.39 mmol) is dissolved in 1.4 ml N,N-dimethylformamide, treated with N,N-Diisopropylethylamine (154 μl; 1.19 mmol) and HATU (66 mg; 0.44 mmol). It is stirred at ambient temperature for 5 minutes before 2.0 mol/l methylamine (341 μl; 0.80 mmol) is added. After 16 hours the reaction mixture is purified via reversed phase chromatography under basic conditions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102684B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-ce864259c9044475a9c280025ec0a9e9 |
| Source note | uspto-grants-2015_08 |