Methyl iodide → HCID 117599530, compound

Participants

Reaction Steps

NaH (562 mg, 23.4 mmol) is added portion wise to a solution of (5-Bromo-2-nitro-phenyl)-phenyl-acetic acid methyl ester (6.8 g, 19.5 mmol) in DMF (100 mL) at room temperature and stirred at room temperature for 3 hours. MeI (8.3 g, 58.5 mmol) is added to the above mixture at 0° C. The mixture is warmed to room temperature slowly and stirred overnight. The mixture is diluted with saturated aqueous NH4Cl solution and extracted with ethyl acetate (3×100 mL). The combined organic phase is washed with water and brine, dried over Na2SO4, filtered and concentrated to give the product.

Provenance & Evidence