Methyl iodide → HCID 86296100, compound

Participants

Reaction Steps

A mixture of 5-(3,5-Dimethyl-isoxazol-4-yl)-3-methyl-3-phenyl-1,3-dihydro-indol-2-one (54 mg, 0.196 mmol) and NaH (5.5 mg, 0.203 mmol) in THF (10 mL) is stirred at room temperature for 1.5 h. MeI (48 mg, 0.338 mmol) is added to the mixture and stirred overnight. The solvent is removed in vacuo. The residue is purified by chromatography (ethyl acetate:petroleum ether=1:2) to give the desired compound.

Provenance & Evidence