N,N'-Dimethylethylenediamine → HCID 86296099, compound

Participants

Reaction Conditions

Reaction Steps

5-(3,5-Dimethyl-isoxazol-4-yl)-3-methyl-3-phenyl-1,3-dihydro-indol-2-one (100 mg, 0.314 mmol), 3-iodopyridine (71 mg, 0.346 mmol), copper (I) iodide (60 mg, 0.314 mmol), N,N′-dimethylethylenediamine (41.5 mg, 0.471 mmol), potassium carbonate (217 mg, 1.571 mmol) are added to a microwave vessel. Dioxane (5 mL) is added and the mixture heated to 140° C. for 30 minutes in a microwave reactor. A further 3-iodopyridine (35 mg, 0.173 mmol) and copper (I) iodide (12 mg, 0.063 mmol) are added. The mixture is again heated to 140° C. for 30 minutes in a microwave reactor. The reaction mixture is filtered. The filtrate is washed with dichloromethane. The volatiles are evaporated and the residue purified using reversed phase HPLC. This afforded the desired product.

Provenance & Evidence