Cesium carbonate → 6-(4-(4-Acetylpiperazin-1-yl)phenylamino)-4-(thiophen-2-ylmethylamino)nicotinamide

Participants

Reaction Steps

A mixture of 6-chloro-4-(thiophen-2-ylmethylamino)nicotinamide (84 mg, 0.314 mmol), 1-(4-(4-aminophenyl)piperazin-1-yl)ethanone (82 mg, 0.374 mmol), Cs2CO3 (200 mg, 0.613 mmol), BINAP (35 mg, 0.056 mmol) and Pd(OAc)2 (25 mg, 0.111 mmol) in dioxane (2 mL) was degassed with Ar, then was stirred at 120 C for 3 h. The mixture was concentrated in vacuo. The residue was purified by HPLC to the titled compound (12 mg). MS 451.4 (M+H); UV 200.0, 244.3 nm; t 0.485 min.

Provenance & Evidence