Diisopropylethylamine → 6-Chloro-4-(1-phenylcyclopropylamino)nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	1-Phenyl-cyclopropylamine	HCID 194549	—
Reactant	4,6-Dichloronicotinamide	HCID 600044	—
Solvent	2-Oxopropiononitrile	HCID 69430	—
Product	6-Chloro-4-(1-phenylcyclopropylamino)nicotinamide	HCID 86664541	36.5%

Reaction Conditions

Temperature	60 °C

Reaction Steps

To a suspension of 4,6-dichloronicotinamide (191 mg, 1 mmol) in AcCN (2 mL) was added 1-phenylcyclopropanamine (160 mg, 1.2 mmol) and DIPEA (0.213 mL, 1.2 mmol). The mixture was heated at 60° C. for 2 days. The mixture was concentrated and purified by column chromatography to give 6-chloro-4-(1-phenylcyclopropylamino)nicotinamide (105 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09102625B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-bf1fb13d2bfd4e1ab3635b34fda50fdf
Source note	uspto-grants-2015_08