HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 513283Generated: October 25, 2026
1-Fluoro-3-nitrobenzene → Tert-butyl 4-(3-nitrophenyl)piperazine-1-carboxylate
https://huagongshe.com/reaction/513283
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Fluoro-3-nitrobenzene | HCID 9823 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Tert-butyl 4-(3-nitrophenyl)piperazine-1-carboxylate | HCID 22330126 | 33.1% |
Reaction Steps
To a solution of 3-fluoronitrobenzene (2 mL, 18.8 mmol) in DMSO (20 mL) was added Boc-piperazine (10 g, 56.4 mmol), after stirring at 100° C. for 3 days, the mixture was poured to ice water, the resulting precipitate was collected by filtration to give tert-butyl 4-(3-nitrophenyl)piperazine-1-carboxylate (1.91 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09102625B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-3970f499b7be4a94a6d0505339b2eead |
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| Source note | uspto-grants-2015_08 |
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