Hydrochloric Acid → HCID 178469848, compound

Participants

Reaction Steps

To a solution of ethyl 4,6-dihydroxynicotinate (1.0 g, 5.43 mmol) in DMF (10 mL) was added NCS (797 mg, 5.96 mmol) and conc. HCl (0.05 mL). After stirring at room temperature for 2.5 h, it was added water and Na2S2O3, the precipitate was collected by filtration, washed with 1N HCl and dried to give ethyl 5-chloro-4,6-dihydroxynicotinate (920 mg).

Provenance & Evidence