3-Fluorobenzylamine → HCID 86664548, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 4,5,6-trichloronicotinate (200 mg, 0.78 mmol) in AcCN (1.5 mL) was added 3-fluorobenzylamine (0.108 mL, 0.94 mmol) and DIPEA (0.167 mL, 0.94 mmol). The mixture was stirred at room temperature for 5 h them at 50° C. until the reaction is over. The solution was cooled and concentrated, the resulting residue was diluted with water, the solid was then collected by filtration to give ethyl 5,6-dichloro-4-(3-fluorobenzylamino)nicotinate (260 mg).

Provenance & Evidence