HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 513290Generated: October 25, 2026
Diisopropylethylamine → 6-Chloro-4-(3-iodobenzylamino)nicotinamide
https://huagongshe.com/reaction/513290
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Iodobenzylamine | HCID 97012 | — |
| Reactant | 4,6-Dichloronicotinamide | HCID 600044 | — |
| Solvent | 2-Oxopropiononitrile | HCID 69430 | — |
| Product | 6-Chloro-4-(3-iodobenzylamino)nicotinamide | HCID 86664546 | 97.9% |
Reaction Steps
To a solution of 4,6-dichloronicotinamide (296 mg, 1.55 mmol) in AcCN (3 mL) was added 3-iodobenzylamine (396 mg, 1.70 mmol) and DIPEA (0.383 mL, 2.32 mmol). After stirring at 80° C. for 15 h, the mixture was concentrated and added water, the resulting precipitate was collected by filtration to give 6-chloro-4-(3-iodobenzylamino)nicotinamide (588 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09102625B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-cb633a02535342f488c2c115d7203c4b |
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| Source note | uspto-grants-2015_08 |
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