HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 513291Generated: October 25, 2026
Sodium Carbonate → HCID 86664550, compound
https://huagongshe.com/reaction/513291
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| Reactant | 6-Chloro-4-(3-iodobenzylamino)nicotinamide | HCID 86664546 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86664550 | HCID 86664550 | 33.1% |
Reaction Steps
To a solution of 6-chloro-4-(3-iodobenzylamino)nicotinamide (200 mg, 0.50 mmol) in Dioxane (2 mL) was added pyridine-4-boronic acid (92 mg, 0.75 mmol) and Pd(PPh3)2Cl2 (56 mg, 0.08 mmol), followed by a solution of Na2CO3 (173 mg, 1.63 mmol) in H2O (1 mL). After stirring at 100° C. for 2 h, it was concentrated and purified by preparative HPLC to give 6-chloro-4-(3-(pyridine-4-yl)benzylamino)nicotinamide (56 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09102625B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-d590ac809d10472a96f0261837414f08 |
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| Source note | uspto-grants-2015_08 |
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