Trifluoroacetic acid → HCID 67502873, compound

Participants

Reaction Steps

The mixture of 4-(2,3-difluorobenzylamino)-6-(4-(piperidin-4-yl)phenylamino)nicotinamide (Example 209) (80 mg, 0.17 mmol), 4-morphonlineacetic acid (100 mg, 0.68 mmol), DIEA (240 μL, 1.36 mmol) in 4 mL NMP was stirred at RT. To it was added BOP (260 mg, 0.68 mmol). The mixture was stirred at RT for overnight. To it was added TFA (0.5 mL). The mixture was subjected to reverse phase preparative HPLC to isolate the title compound (59 mg). MS found for C30H34F2N6O3 as (M+H)+ 565.5. UV: λ=259 nm. 1H NMR: (CD3OD) δ 8.17 (1H, s), 7.33 (2H, d, J=8.0 Hz), 7.26 (1H, m), 7.16 (1H, m), 7.13-7.07 (3H, m), 5.79 (1H, s), 4.68 (2H, m), 4.55 (2H, s), 4.41-4.27 (2H, m), 3.96 (4H, m), 3.84 (2H, m), 2.95-2.82 (3H, m), 1.96 (2H, m), 1.70 (2H, m) ppm.

Provenance & Evidence