反应详情

A 250 mL round bottom flask was charged with 4-Bromo-2-nitrobenzene (19.2 g, 69.04 mmol), and triethyl phosphate (84 mL, 483.28 mmol). Then, at 160° C. to 165° C., the mixture was heated under reflux for 14 hours. After the reaction was completed, the remaining triethyl phosphate was removed by vacuum distillation. The resultant product was diluted with a mixed solvent of MeOH:H2O=1:1, and the produced solid was filtered. The obtained solid was washed with a mixed solvent of MeOH:H2O=1:1 and petroleum ether.

1. temperatureThen, at 160° C. to 165° C., the mixture was heated
2. temperatureunder reflux for 14 hours
3. customthe remaining triethyl phosphate was removed by vacuum distillation
4. additionThe resultant product was diluted with a mixed solvent of MeOH
5. filtrationH2O=1:1, and the produced solid was filtered
6. washThe obtained solid was washed with a mixed solvent of MeOH