HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Chloro-4-fluoro-2-nitrobenzene-1-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Chloro-4-fluoro-2-nitroaniline | HCID 517835 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Chloro-4-fluoro-2-nitrobenzene-1-sulfonyl chloride | HCID 86669752 | 105.3% |
Reaction Steps
In a similar fashion using route 3a general procedure 10, SOCl2 (2.8 ml, 28.8 mmol) in water (15 ml), CuCl (26 mg, 0.26 mmol), 5-chloro-4-fluoro-2-nitroaniline (1 g, 5.2 mmol), NaNO2 (522 mg, 7.5 mmol) and conc. HCl (10 ml) gave the title compound (1.5 g) which was used in the next step without further purification. The structure was confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-6683550bfa624031943e17fa5b3a0d0e |
| Source note | uspto-grants-2015_08 |