HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Fluoro-2-nitrobenzene-1-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Fluoro-2-nitroaniline | HCID 67769 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Fluoro-2-nitrobenzene-1-sulfonyl chloride | HCID 2759046 | 81.5% |
Reaction Steps
In a similar fashion using route 3a general procedure 10, SOCl2 (51.4 g, 704 mmol) in water (260 ml), CuCl (0.65 g, 6.4 mmol), 2-nitro 4-fluro-aniline (20 g, 128 mmol), NaNO2 (12.7 g, 184 mmol) and conc. HCl (200 ml) gave the title compound (25 g, 81%) which was used in the next step without further purification. The structure was confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-f9f7fe10c3c54048bf8df7f10a21fec1 |
| Source note | uspto-grants-2015_08 |