HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 5-Chloroquinolin-8-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 5-Chloro-8-nitroquinoline | HCID 242755 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 5-Chloroquinolin-8-amine | HCID 224860 | 98% |
Reaction Steps
In the similar fashion using route 6 general procedure 14, 5-chloro-8-nitroquinoline (Intermediate 25) (500 mg, 2.40 mmol), Raney nickel (100 mg, 20% wt), hydrazine hydrate (0.5 ml, 9.62 mmol) and MeOH/THF (10 ml, 4:1), gave the title compound (420 mg, 98%) which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-e36d20ac99d24f3eadf9e34ba0fd878a |
| Source note | uspto-grants-2015_08 |