HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 513382Generated: October 30, 2026
N-methyl-N-phenyl-hydrazine → 8-Amino-7-quinolinol
https://huagongshe.com/reaction/513382
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-methyl-N-phenyl-hydrazine | HCID 36299 | — |
| Reactant | 7-Hydroxyquinoline | HCID 135426866 | — |
| Product | 8-Amino-7-quinolinol | HCID 135702826 | 31% |
Reaction Steps
7-Hydroxyquinoline (1.1 g, 7.5 mmol) and 1-phenyl-1-methylhydrazine (0.92 g, 7.5 mmol) were combined and heated at 130° C. under nitrogen for 16 h. After cooling the solvent was partially evaporated, the crude product was purified by column chromatography with heptane/EtOAc (1:1) as the eluent to give the title compound (370 mg, 31%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09102688B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-4c8eb3cee3134350b2a91b3a812b7a7e |
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| Source note | uspto-grants-2015_08 |
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