HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Methyl-8-quinolinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ammonium Sulfite | HCID 25041 | — |
| Reactant | 3-Methylquinolin-8-ol | HCID 4332281 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Methyl-8-quinolinamine | HCID 15783794 | 91.3% |
Reaction Steps
3-methylquinolin-8-ol (Intermediate 30) (150 mg, 0.9 mmol) and ammonium sulphite (250 mg, 1.8 mmol) were added to aqueous ammonia (3 ml) and heated for 48 h. After cooling, water was added and the mixture was extracted with DCM. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (130 mg, 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-deb45c358e1b499eb3e02cc0c03b2144 |
| Source note | uspto-grants-2015_08 |