HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycerol → 5-Fluoro-8-nitroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycerol | HCID 753 | — |
| Reactant | Sodium 3-nitrobenzenesulfonate | HCID 31389 | — |
| Reactant | 5-Fluoro-2-nitroaniline | HCID 75399 | — |
| Reactant | Sulfuric acid hydrate (1:1) | HCID 21910475 | — |
| Product | 5-Fluoro-8-nitroquinoline | HCID 153972 | 60% |
Reaction Steps
In a similar fashion using route 10 general procedure 20, 5-fluoro-2-nitroaniline (1.0 g, 6.4 mmol), glycerol (1.83 g, 19.86 mmol), 3-nitrobenzenesulfonic acid sodium salt (1.8 g, 8.33 mmol) and H2SO4/H2O (1.2 ml, 7:5) gave the title compound (500 mg, 60%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-81664ce63b6e4ffbbcbeb00f2e00e31c |
| Source note | uspto-grants-2015_08 |