HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycerol → 5-Chloro-6-fluoro-8-nitroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycerol | HCID 753 | — |
| Reactant | Sodium 3-nitrobenzenesulfonate | HCID 31389 | — |
| Reactant | 5-Chloro-4-fluoro-2-nitroaniline | HCID 517835 | — |
| Reactant | Sulfuric acid hydrate (1:1) | HCID 21910475 | — |
| Product | 5-Chloro-6-fluoro-8-nitroquinoline | HCID 68182941 | 67% |
Reaction Steps
In a similar fashion using route 10 general procedure 20, 5-chloro-4-fluoro-2-nitroaniline (1.0 g, 5.2 mmol), glycerol (1.5 g, 16.2 mmol), 3-nitrobenzensulfonic acid sodium salt (1.52 g, 6.7 mmol) and H2SO4/H2O (6 ml, 7:5) gave the title compound (790 mg, 67%) which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-40b4953077fb488c95d4dd8894d37b78 |
| Source note | uspto-grants-2015_08 |