HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycerol → 5,6-Dimethyl-8-nitroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycerol | HCID 753 | — |
| Reactant | Sodium 3-nitrobenzenesulfonate | HCID 31389 | — |
| Reactant | 4,5-Dimethyl-2-nitrobenzenamine | HCID 81445 | — |
| Reactant | Sulfuric acid hydrate (1:1) | HCID 21910475 | — |
| Product | 5,6-Dimethyl-8-nitroquinoline | HCID 110464 | 16.5% |
Reaction Steps
In a similar fashion using route 10 general procedure 20, 4,5-dimethyl-2-nitroaniline (1.0 g, 6.0 mmol), glycerol (1.0 g, 11.4 mmol), 3-nitrobenzenesulfonic acid sodium salt (2.2 g, 9.6 mmol) and H2SO4/H2O (3 ml, 7:1), further reagents added over 4 days, gave the title compound (200 mg, 16%) which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-2bc6e920bddf4f368ea54ec7ee8a4292 |
| Source note | uspto-grants-2015_08 |