HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 5-Methylquinolin-8-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 5-Methyl-8-nitroquinoline | HCID 6427839 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Product | 5-Methylquinolin-8-amine | HCID 12846625 | 118.9% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 5-methyl-8-nitroquinoline (Intermediate 32) (950 mg, 5.05 mmol), tin (II) chloride (2.87 g, 15.1 mmol) and 6 N HCl (5 drops) gave the title compound (950 mg, >100% crude) which was used in the next step without purification. The structure was confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5e1443f4b070423888d2b5cf1fb5e649 |
| Source note | uspto-grants-2015_08 |