HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 6-Fluoroquinolin-8-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | Quinoline, 6-fluoro-8-nitro- | HCID 154273 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Product | 6-Fluoroquinolin-8-amine | HCID 13227992 | 74.1% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 6-fluoro-8-nitroquinoline (Intermediate 36) (1.0 g, 5.41 mmol), tin (II) chloride (3.08 g, 16.2 mmol) and 6N HCl (5 drops) gave the title compound (650 mg, 74%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c5a649fabcfb4a2fbff7a40b2275815b |
| Source note | uspto-grants-2015_08 |