HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycerol → 7-Methoxyquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycerol | HCID 753 | — |
| Reactant | 3-Methoxyaniline | HCID 10824 | — |
| Reactant | Sodium 3-nitrobenzenesulfonate | HCID 31389 | — |
| Reactant | Sulfuric acid hydrate (1:1) | HCID 21910475 | — |
| Product | 7-Methoxyquinoline | HCID 78666 | 14% |
Reaction Steps
In a similar fashion using route 10 general procedure 20, 3-methoxyaniline (1.0 g, 8.12 mmol), glycerol (2.32 g, 25.2 mmol), 3-nitrobenzenesulfonic acid sodium salt (2.4 g, 10.6 mmol) and H2SO4/H2O (6 ml, 7:5) gave the title compound (170 mg, 14%) after purification by column chromatography with n-hexane/EtOAc (17:3) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-6814edb5830d44ef92a477e77bee47d9 |
| Source note | uspto-grants-2015_08 |